Ovulation and artificial insemination rates have been observed to decrease in sheep and cows when exposed to dietary phytoestrogens at concentrations greater than 25 mg/kg DM.A grazing trial was undertaken to investigate the effects of coumestrol and other key phytoestrogens on the superovulatory response, embryo numbers and quality in beef cows gr
Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription.
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted.Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular proliferation required to support virus replication.We re
Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study.
In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points.However, under random-effects assumption the multivariate estimation is more complex (a
Performing a bone gammagraphy
In the Nuclear Medicine service multitude of diagnostic tests are performed, SMOKE ACC being one of them the bone gammagraphy that acquires a very important role both by the high demand for this test, because of its simplicity and in the realization by its high sensitivity.The bone gammagraphy as opposed to conventional radiological techniques not
Linking cortical microtubule attachment and exocytosis [version 1; referees: 2 approved]
Exocytosis is a fundamental cellular process whereby secreted molecules are packaged into vesicles that move along cytoskeletal filaments and fuse with the plasma membrane.To function optimally, cells are strongly dependent on precisely controlled delivery of Basket exocytotic cargo.In mammalian cells, microtubules serve as major tracks for vesicle