Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription.

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted.Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular proliferation required to support virus replication.We re

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Performing a bone gammagraphy

In the Nuclear Medicine service multitude of diagnostic tests are performed, SMOKE ACC being one of them the bone gammagraphy that acquires a very important role both by the high demand for this test, because of its simplicity and in the realization by its high sensitivity.The bone gammagraphy as opposed to conventional radiological techniques not

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